Iridium-catalyzed isomerization of primary allylic alcohols under mild reaction conditions

L Mantilli, C Mazet

Index: Mantilli, Luca; Mazet, Clement Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4141 - 4144

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Citation Number: 52

Abstract

The isomerization of primary allylic alcohols into the corresponding aldehydes has been accomplished using an analogue of Crabtree's iridium hydrogenation catalyst and by adequately tuning the experimental conditions. A wide range of substrates is converted quantitatively into the desired aldehyde at room temperature in expedient reaction times by using catalyst loading as low as 0.25 mol%.