Synthesis of aminoanthraquinone derivatives and their in vitro evaluation as potential anti-cancer drugs

…, G Bar-Ad, Z Tashma, R Ben-Shoshan, I Ringel…

Index: Katzhendler; Gean; Bar-Ad; Tashma; Ben-Shoshan; Ringel; Bachrach; Ramu European Journal of Medicinal Chemistry, 1989 , vol. 24, # 1 p. 23 - 30

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Citation Number: 25

Abstract

Abstract Anthraquinones, monosubstituted by aminoalkylamino side chains at positions 1, 2 or disubstituted at positions 1, 5 or 1, 8 were prepared. Their in vitro cytotoxic activity (ED 50) was evaluated using: 1) P388 murine leukemia cells and 2) a subline of these cells resistant to doxorubicin (P388/ADR).