Studies on hindered phenols and analogs. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation

…, T Kurumada, K Hasegawa, H Horikoshi

Index: Yoshioka; Fujita; Kanai; Aizawa; Kurumada; Hasegawa; Horikoshi Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 421 - 428

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Citation Number: 254

Abstract

Design Ethyl 2-(4-chlorophenoxy)-2-methylpropionate (2, clofibrate) l'and the corresponding sulfur analogue, 12 ethyl 2-[(3, 5-di-tert-butyl-4-phenyl) thio]-2-methylpropionate (3: R'= H, R2= CH3), are well-known hypolipidemic agents.(5)(a) Hasegawa, K.; Iwamoto, K.; Ohno, S.; Koga, T.; Matsushita,