Synthesis of 2 (3H)??benzoxazolone and 2 (3H)??benzothiazolone derivatives as potential beta??3??adrenergic receptor ligands (part 2)

JF Delhomel, S Yous, P Depreux…

Index: Delhomel; Yous; Depreux; Lesieur Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 3 p. 633 - 639

Full Text: HTML

Citation Number: 5

Abstract

Abstract Adrenoceptors beta-3-subtype mediate lipolysis and in the search for potential beta- 3-adrenergic receptors agonists for the treatment of obesity, we designed new arylethanolamines (structures 4, 5) and aryloxypropanolamines (structures 6, 7) derived from 2 (3H)-benzoxazolone and 2 (3H)-benzothiazolone.