Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2, 4, 4a, 5-tetrahydro-3H-indeno [1, 2-c] pyridazin-3-ones: rigid structures derived from CI- …

I Sircar, BL Duell, MH Cain, SE Burke…

Index: Sircar; Duell; Cain; Burke; Bristol Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2142 - 2148

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Citation Number: 35

Abstract

Recently we reported the positive inotropic activity of 4, 5-dihydro-6-[4-(1H-imidazol-l-yl) phenyl]-3 (2H)-pyridazinone (Ia, CI-914) 1a1b and related compounds from our laboratory. It has been found that the introduction of a methyl substituent at the 5-position of the 4, 5- dihydropyridazinone ring (DHPZ) in CI-914 augments activity and leads to a more potent compound (Ib, CI-930). In order to extend the structure-activity relationships of these freely ...