In vitro antioxidant and cytotoxic activity of some synthetic riparin-derived compounds

…, CA Câmara, JM Barbosa Filho, SJC Gutierrez…

Index: Nunes, Geandra B.L.; Policarpo, Paola R.; Costa, Luciana M.; Silva, Teresinha G. Da; Militao, Gardenia Carmen G.; Camara, Celso A.; Filho, Jose Maria Barbosa; Gutierrez, Stanley Juan C.; Islam, Mohammed T.; De Freitas, Rivelilson M. Molecules, 2014 , vol. 19, # 4 p. 4595 - 4607

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Citation Number: 8

Abstract

Abstract: This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). ...