Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors

M Dixit, BK Tripathi, AK Tamrakar, AK Srivastava…

Index: Dixit, Manish; Tripathi, Brajendra K.; Tamrakar, Akhilesh K.; Srivastava, Arvind K.; Kumar, Brijesh; Goel, Atul Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 727 - 734

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Citation Number: 48

Abstract

Protein tyrosine phosphatase 1B (PTP-1B) is an enzyme that plays a critical role in down- regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of hydroxy benzofuran methyl ketones and their naturally mimicking dimers and linear and angular furanochalcones and flavones have ...