Back to natural cinchona alkaloids: highly enantioselective Michael addition of malononitrile to enones

A Russo, A Perfetto, A Lattanzi

Index: Russo, Alessio; Perfetto, Alessandra; Lattanzi, Alessandra Advanced Synthesis and Catalysis, 2009 , vol. 351, # 18 p. 3067 - 3071

Full Text: HTML

Citation Number: 48

Abstract

Abstract An efficient and convenient highly enantioselective Michael addition of malononitrile to enones has been developed by using quinine as the organocatalyst. The adducts were isolated in excellent yield and high asymmetric induction (up to 95% ee). An easy route to difficultly accessible ester derivatives has been also disclosed.