Effect of structural modification of the hydantoin ring on anticonvulsant activity

S Cortes, ZK Liao, D Watson…

Index: Cortes; Liao; Watson; Kohn Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 601 - 606

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Citation Number: 102

Abstract

Selectively substituted hydantoins 1 (15 examples), 4-hydroxy-2-imidazolidinones 2 (13 examples), 2-imidazolones 3 (10 examples), 2-imidazolidinones 4 (four examples), vicinal diamines 5 (two examples), and simple amino acid derivatives 6 (four examples) have been prepared and evaluated in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole seizure threshold (sc Met), and rotorod (Tox) tests. The medium ...