Journal of Medicinal Chemistry

Monoamine Oxidase Inhibitors--II. Some Amino and Dialkylaminobenzyl Hydrazines and their Acyl Derivatives

TS Gardner, E Wenis, J Lee

Index: Gardner,T.S. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 3, p. 241 - 252

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Citation Number: 6

Abstract

In the first paper of this series, l it was shown that acyl derivatives of benzylhydrazine (I) are potent monoamine oxidase (MAO) inhibitors. These compounds are characterized by a long duration of activity (more than 4 days and usually up to 30 days in the test described) 2 and are classified as irreversible MA0 inhibitor^.^ Udenfriend and co-workers3, have shown that some alkaloids of the Harmala group are reversible and short-acting M90 inhibitors. We ...