Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1, 4-naphthoquinones

VS Khodade, AT Dharmaraja, H Chakrapani

Index: Khodade, Vinayak S.; Dharmaraja, Allimuthu T.; Chakrapani, Harinath Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3766 - 3769

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Citation Number: 9

Abstract

Here we report a series of 2-aryl-3-amino-1, 4-naphthoquinones that generated reactive oxygen species (ROS) such as superoxide and hydrogen peroxide upon incubation in pH 7.4 under ambient aerobic conditions. ROS generation from these compounds was sensitive to structural modifications at the 3-amino position and a 2-aryl substituent promoted ROS generation. A number of these compounds were found to induce DNA damage in the ...