Methylation of Benzimidazole and Benzothiazole Carboxaldoximes1

EJ Poziomek, RH Poirier, RD Morin…

Index: Poziomek,E.J. et al. Journal of Organic Chemistry, 1963 , vol. 28, p. 1411 - 1413

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Citation Number: 2

Abstract

I I1 are difficult to alkylate it has been reported that nitromethane is a better choice of~ olvent.~ When the ring nitrogen is hindered sterically, alkylation is very difficult and in the case of quinoline-2-aldoxime it was U~ SUCC~ SS~ U~.~~ In the case where a methyl group at the 6-position of picolinaldehyde oxime hinders the ring nitrogen sterically, it was shown that alkylation occurs on the nitrogen of the oxime rather than on the ring. 6