Unparalleled rates for the activation of aryl chlorides and bromides: Coupling with amines and boronic acids in minutes at room temperature

JP Stambuli, R Kuwano…

Index: Stambuli, James P.; Kuwano, Ryoichi; Hartwig, John F. Angewandte Chemie - International Edition, 2002 , vol. 41, # 24 p. 4746 - 4748

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Citation Number: 291

Abstract

Oxidative addition initiates most palladium-catalyzed cross-couplings [1] and is often rate- limiting for reactions of aryl chlorides [2] and deactivated aryl bromides.[3] This addition usually occurs to an unsaturated complex formed from ligand dissociation or after transformation of a precatalyst to the true catalyst.[4] Although the elementary oxidative addition step could occur to the same Pd0 intermediate and at the same rate when ...