Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay

…, W Zhu, X Tan, X Luo, J Shen, K Chen…

Index: Liu, Hong; Gao, Zhao-Bing; Yao, Zhiyi; Zheng, Suxin; Li, Yang; Zhu, Weiliang; Tan, Xiaojian; Luo, Xiaomin; Shen, Jianhua; Chen, Kaixian; Hu, Guo-Yuan; Jiang, Hualiang Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 83 - 93

Full Text: HTML

Citation Number: 32

Abstract

Potassium ion (K+) channels are attractive targets for drug discovery because of the essential roles played in biological systems. However, high-throughput screening (HTS) cannot be used to screen K+ channel blockers. To overcome this disadvantage of HTS, we have developed a virtual screening approach for discovering novel blockers of K+ channels. On the basis of a three-dimensional model of the eukaryotic K+ channels, molecular ...