Tetrahedron letters

A synthetic approach towards the aromatic macrocyclic core of diazonamide A based on sp 2-sp 2 coupling protocols

A Boto, M Ling, G Meek, G Pattenden

Index: Boto, Alicia; Ling, Matthew; Meek, Graham; Pattenden, Gerald Tetrahedron Letters, 1998 , vol. 39, # 44 p. 8167 - 8170

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Citation Number: 40

Abstract

The scope for a range of sp2-sp2 coupling protocols to elaborate the phenyl-indole, indole- oxazole, oxazole-oxazole, and quaternary carbon units in the marine natural product diazonamide A 1 are described, leading to the synthesis of the benzofuran oxazoles 11a and 18, the benzofuran/biphenyl/indole 16, and the indole-bis-oxazole, 25.