Tunable, Chemoselective Amination via Silver Catalysis

JW Rigoli, CD Weatherly, JM Alderson…

Index: Rigoli, Jared W.; Weatherly, Cale D.; Alderson, Juliet M.; Vo, Brian T.; Schomaker, Jennifer M. Journal of the American Chemical Society, 2013 , vol. 135, # 46 p. 17238 - 17241

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Citation Number: 22

Abstract

Organic N-containing compounds, including amines, are essential components of many biologically and pharmaceutically important molecules. One strategy for introducing nitrogen into substrates with multiple reactive bonds is to insert a monovalent N fragment (nitrene or nitrenoid) into a C–H bond or add it directly to a C C bond. However, it has been challenging to develop well-defined catalysts capable of promoting predictable and ...