Tetrahedron Letters

Palladium (II)-catalyzed asymmetric cycloisomerization of enynes for axially chiral biaryl construction

N Kadoya, M Murai, M Ishiguro, J Uenishi, M Uemura

Index: Kadoya, Nobuaki; Murai, Masato; Ishiguro, Masako; Uenishi, Jun'Ichi; Uemura, Motokazu Tetrahedron Letters, 2013 , vol. 54, # 6 p. 512 - 514

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Citation Number: 9

Abstract

Palladium (II)-catalyzed asymmetric cycloisomerization of enynes with (R)-binap gave axially chiral biaryls with up to 99% ee. The reactivity and enantioselectivity depended on the nature and position of substituent of the arene ring. The enynes with ortho methoxy arene at alkyne terminus gave chiral biaryls with good enantioselectivity.