Nickel??Catalyzed Hydroheteroarylation of Vinylarenes

…, N Kashihara, KS Kanyiva, T Hiyama

Index: Nakao, Yoshiaki; Kashihara, Natsuko; Stephen Kanyiva, Kyalo; Hiyama, Tamejiro Angewandte Chemie - International Edition, 2010 , vol. 49, # 26 p. 4451 - 4454

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Citation Number: 96

Abstract

The metal-catalyzed hydroarylation of vinylarenes is a versatile and highly atom-economical way to obtain 1, 1-diarylmethyl structural motifs that are found in many pharmaceuticals and biologically active molecules.[1] This catalytic reaction can be classified into two major types depending on the possible mechanism (Scheme1). The reaction can be initiated by oxidative addition of aromatic CÀH bonds to a metal catalyst, before hydrometalation and ...