Highly Potent 1, 4-Benzothiazine Derivatives as KATP-Channel Openers 1

V Cecchetti, V Calderone, O Tabarrini…

Index: Cecchetti; Fravolini; Fringuelli; Schiaffella; Mascellani; Pagella; Rugarli Farmaco, Edizione Scientifica, 1987 , vol. 42, # 1 p. 61 - 75

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Citation Number: 39

Abstract

A series of 1, 4-benzothiazines, suitably functionalized at the N-4 and C-6 positions, arising from the replacement of a benzopyran-based structure of cromakalim with a 1, 4- benzothiazine nucleus, has been synthesized as potassium channel openers (KCOs). Most