Ligand-controlled C (sp3)–H arylation and olefination in synthesis of unnatural chiral α–amino acids
…, S Li, Y Deng, H Fu, BN Laforteza, JE Spangler…
Index: He, Jian; Li, Suhua; Deng, Youqian; Fu, Haiyan; Laforteza, Brian N.; Spangler, Jillian E.; Homs, Anna; Yu, Jin-Quan Science, 2014 , vol. 343, # 6176 p. 1216 - 1220
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Citation Number: 161
Abstract
Abstract The use of ligands to tune the reactivity and selectivity of transition metal catalysts for C (sp 3)–H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C (sp 3)–H arylation using pyridine and quinoline derivatives: The former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ...
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