Utilization of n-Alkyl Methyl Ketones in the Pfitzinger Reaction1

HR Henze, DW Carroll

Index: Henze; Carroll Journal of the American Chemical Society, 1954 , vol. 76, p. 4580,4582

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Citation Number: 17

Abstract

X series of Pfitzinger condensations, utilizing n-alkyl methyl ketones (alkyl= methyl through hexyl), has been accoinplished. The unsymmetrical ketones produce two isomeric cinchoninic acids, a 2-monosubstituted acid and a 2,: j-disubstituted acid, the monosubstituted compound usually being formed in the larger amount. A new sequence of syntheses has been developed in order to establish the structure of one series of these ...