Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981

Wataru Fukasawa, Natsuki Mori, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Moe Nakajima, Takahito Ouchi, Kenichi Nonaka, Hiroki Kojima, Hirotaka Matsuo, Satoshi Ōmura, Kazuro Shiomi

Index: 10.1038/s41429-018-0041-3

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Abstract

A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated as N-acetyl-l-phenylalanyl-l-prolinol. It showed moderate antimalarial activity but did not show cytotoxicity or any other antimicrobial property.