Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators

…, TP Selby, JH Freudenberger, TM Stevenson…

Index: Lahm, George P.; Selby, Thomas P.; Freudenberger, John H.; Stevenson, Thomas M.; Myers, Brian J.; Seburyamo, Gilles; Smith, Ben K.; Flexner, Lindsey; Clark, Christopher E.; Cordova, Daniel Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4898 - 4906

Full Text: HTML

Citation Number: 319

Abstract

A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure–activity, and biological results are presented.