Inhibition of monoamine oxidase B by N-methyl-2-phenylmaleimides

CI Manley-King, G Terre'Blanche, N Castagnoli…

Index: Manley-King, Clarina I.; Terre'Blanche, Gisella; Castagnoli Jr., Neal; Bergh, Jacobus J.; Petzer, Jacobus P. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3104 - 3110

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Citation Number: 18

Abstract

Based on a recent report that 1-methyl-3-phenylpyrrolyl analogues are moderately potent reversible inhibitors of the enzyme monoamine oxidase B (MAO-B), a series of structurally related N-methyl-2-phenylmaleimidyl analogues has been prepared and evaluated as inhibitors of MAO-B. In general, the maleimides were more potent competitive inhibitors than the corresponding pyrrolyl analogues. N-Methyl-2-phenylmaleimide was found to be the ...