Synthesis of thromboxane A2 analogs: DL-9, 11: 11, 12-dideoxa-9, 11: 11, 12-diepithiothromboxane A2

S Ohuchida, N Hamanaka…

Index: Ohuchida, Shuichi; Hamanaka, Nobuyuki; Hayashi, Masaki Journal of the American Chemical Society, 1981 , vol. 103, # 15 p. 4597 - 4599

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Citation Number: 14

Abstract

Then we wanted to check if the formation of 6 by thermolysis of 1 was a general phenomenon. Indeed 2, 5 disubstitution could prevent the 1, 5 migration of the 1-phenyl substituent. We thus reacted 2 with tolane. In fact we noted that the reaction was more sluggish and gave a lower yield but, nevertheless, produced the expected 1- phosphanorbornadiene 10. l2