Amine??Catalyzed [3+ 2] Huisgen Cycloaddition Strategy for the Efficient Assembly of Highly Substituted 1, 2, 3??Triazoles

L Wang, S Peng, LJT Danence, Y Gao…

Index: Wang, Lei; Peng, Shiyong; Danence, Lee Jin Tu; Gao, Yaojun; Wang, Jian Chemistry - A European Journal, 2012 , vol. 18, # 19 p. 6088 - 6093

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Abstract

Abstract An enamine-catalyzed strategy has been utilized to fully promote the Huisgen [3+ 2] cycloaddition with a broad spectrum of carbonyl compounds and azides, thereby permitting the efficient assembly of a vast pool of highly substituted 1, 2, 3-triazoles. In particular, the employment of commonly used and commercially available carbonyl compounds has resulted in the introduction of a diverse set of functional groups, such as alkyl, aryl, nitrile, ...