Tetrahedron

Synthesis of novel 5-fluorouracil derivatives with 1, 4-oxaheteroepane moieties

…, MA Trujillo, J Campos, MA Gallo, A Espinosa

Index: Gomez, Jose A.; Trujillo, Maria A.; Campos, Joaquin; Gallo, Miguel A.; Espinosa, Antonio Tetrahedron, 1998 , vol. 54, # 43 p. 13295 - 13312

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Citation Number: 13

Abstract

A series of new ring-expanded isosteres (1, 4-oxaheteroepanes) of Ftorafur [1-(2- tetrahydrofuranyl)-5-fluorouracil] has been synthesized. The branching of C-3 of the seven- membered cycloacetal and the electronegativity of the Y group on the 3-YCH2 moities (Y being H, I and Cl), respectively, seem to direct their regiochemical and stereochemical outcome. The more electronegative the group Y is (and favouring accordingly the ...