Tetrahedron letters

A new synthesis of α-amino acids (E)-β, γ-enol ethers

M Daumas, L Vo-Quang, Y Vo-Quang, F Le Goffic

Index: Daumas, M.; Vo-Quang, L.; Vo-Quang, Y.; le Goffic, F. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5121 - 5124

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Citation Number: 10

Abstract

Abstract Various N-protected amino acids bearing an enol ether side chain were synthesized by a new method allowing a great versatility in the introduction of both the N- protective groups and the enol ether moieties. This method deals with a Wittig-Horner condensation to afford the α, β-dehydro homoserine ethers derivatives, followed by a regio and stereo selective isomerization into β, γ-enol ethers.