Manganese(II/III/I)-Catalyzed C–H Arylations in Continuous Flow

Cuiju Zhu, João C.A. Oliveira, Zhigao Shen, Huawen Huang, Lutz Ackermann

Index: 10.1021/acscatal.8b00166

Full Text: HTML

Abstract

Versatile manganese-catalyzed C–H arylations on synthetically meaningful pyridines were accomplished with sustainable MnCl2 as the catalyst. The oxidative C–H functionalizations proved viable with a user-friendly and safe continuous flow setup by weak amide-assisted C–H cleavage via a facile C–H activation regime.