1, 3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1, 6-glucan synthesis inhibitors

J Kuroyanagi, K Kanai, Y Sugimoto, T Horiuchi…

Index: Kuroyanagi, Jun-Ichi; Kanai, Kazuo; Sugimoto, Yuuichi; Horiuchi, Takao; Achiwa, Issei; Takeshita, Hiroshi; Kawakami, Katsuhiro Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 21 p. 7593 - 7606

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Citation Number: 15

Abstract

Synthesis and in vitro antifungal evaluations of 1, 3-benzoxazole-7-carbonitrile 3, 1, 3- benzoxazole-4-carbonitrile 4, benzofuran 5, benzoxazine 7, and benzimidazole 8 were reported. Among them, 1, 3-benzoxazole-4-carbonitrile was found to be a superior scaffold structure with moderate growth inhibition against Candida species. 1, 3-Benzoxazole-4- carbonitrile 6 showed potent activity against Candida species compared to 5-desmethyl ...