Thiostrepton. Degradation products and structural features

M Bodanszky, J Fried, JT Sheehan…

Index: Bodanszky,M. et al. Journal of the American Chemical Society, 1964 , vol. 86, p. 2478 - 2490

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Citation Number: 52

Abstract

Thiostrepton, an antibiotic from cultures of Streptomyces azureus, has a molecular weight of about 1650. From its acid hydrolysates, L-threonine, L-alanine (2 moles), L-isoleucine, D- cystine, and two thiazole-4-carboxylic acid derivatives, designated as thiostreptoic acid and thiostreptine, were isolated Derivatives of 8-hydroxyquinaldic acid also found in the hydrolysates of the antibiotic were shown, however, not to be present as such in the ...