Fluorous tagged N-hydroxy phthalimide for the parallel synthesis of O-aryloxyamines

FS Gaucher-Wieczorek, LT Maillard…

Index: Gaucher-Wieczorek, Florence S.; Maillard, Ludovic T.; Badet, Bernard; Durand, Philippe Journal of Combinatorial Chemistry, 2010 , vol. 12, # 5 p. 655 - 658

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Citation Number: 5

Abstract

The parallel synthesis of O-aryloxyamines remains an unfulfilled need in the field of medicinal chemistry and fragment-based approaches. To fill this gap a solution-phase two- step process based on (1) a copper-catalyzed cross-coupling of aryl boronic acids with a fluorous tagged N-hydroxyphthalimide, and (2) a supported aminolysis was designed and optimized using Taguchi's method. A library of O-aryloxyamines was synthesized in high ...