A highly selective coumarin-based chemosensor for the sequential detection of Fe3+ and pyrophosphate and its application in living cell imaging

Wei Wang, Jian Wu, Qinglei Liu, Yan Gao, Huimin Liu, Bing Zhao

Index: 10.1016/j.tetlet.2018.04.007

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Abstract

A new chemosensor based on coumarin FB has been designed and synthesized for the detection of Fe3+ and PPi. FB displayed a high affinity to Fe3+ in the presence of other competing cations. The resulting FB-Fe3+ complex displayed highly sensitivity to PPi via Fe3+ displacement approach. The Fe3+ and PPi recognition processes is rapid and reversible, the detection limits of FB to Fe3+ and FB-Fe3+ complex to PPi were estimated to be 8.73×10-8M and 1.25×10-8M, respectively. The good biocompatibility of FB enables the investigation of fluorescent response for Fe3+ and PPi in living cells by confocal microscope. A B3LYP/6-31G (d, p) basis set was employed for optimization of FB and FB-Fe3+ complex.