Trichorenins A–C, Algicidal Tetracyclic Metabolites from the Marine-Alga-Epiphytic Fungus Trichoderma virens Y13-3

Zhen-Zhen Shi, Feng-Ping Miao, Sheng-Tao Fang, Xiu-Li Yin, Nai-Yun Ji

Index: 10.1021/acs.jnatprod.8b00164

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Abstract

Three novel polyketide-like metabolites, trichorenins A–C (1–3), with a unique tetracyclic carbon skeleton were obtained from the culture of Trichoderma virens Y13-3, an epiphyte of the marine red alga Gracilaria vermiculophylla. Their structures and relative configurations were established by analysis of 1D/2D NMR and MS data, and their absolute configurations were unequivocally assigned by X-ray diffraction and ECD spectra aided by quantum chemical calculations. Compounds 1–3 exhibited potent inhibition against two marine phytoplankton species, Chattonella marina and Karlodinium veneficum.