Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata

Jiabao Liu, Pankaj Pandey, Xiaojuan Wang, Xinzhu Qi, Jiabao Chen, Hua Sun, Peicheng Zhang, Yuanqing Ding, Daneel Ferreira, Robert J. Doerksen, Mark T. Hamann, Shuai Li

Index: 10.1021/acs.jnatprod.7b00934

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Abstract

Five new dibenzocyclooctadiene lignans, longipedlignans A–E (1–5), five new tetrahydrobenzocyclooctabenzofuranones (6–10), and 18 known analogues (11–28) were isolated from the roots of Kadsura longipedunculata. Compounds 6–10 are new spirobenzofuranoid–dibenzocyclooctadiene-type lignans. Their structures and absolute configurations were established using a combination of MS, NMR, and electronic circular dichroism data. Spirobenzofuranoids 6 and 15 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol-induced toxicity in HepG2 cells with cell survival rates at 10 μM of 52.2% and 50.2%, respectively.