Organic Chemistry Frontiers 2018-03-30

Directing group assisted ZnI2-catalyzed cyclopropanation of indoles via 2-furylcarbenoids

Wei Chen, Dong-Sheng Ji, Yong-Chun Luo, Zhu-Yin Wang, Peng-Fei Xu

Index: 10.1039/C8QO00232K

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Abstract

A directing group promoting the cyclopropanation of indoles with 2-furylcarbenoids has been developed. These carbenes are derived from enynones and cost-effective ZnI2 is employed as the catalyst for the efficient construction of various polycyclic compounds under mild reaction conditions.

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