Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents

TM Bare, CD McLaren, JB Campbell…

Index: Bare; McLaren; Campbell; Firor; Resch; Walters; Salama; Meiners; Patel Journal of Medicinal Chemistry, 1989 , vol. 32, # 12 p. 2561 - 2573

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Citation Number: 67

Abstract

" Method A= EtOCH= C (CO, Et),(4), 120" C; method A'= PhOPh, 235-255 OC; method B= R6'COCH (C0, Et),(6), PPA, 120" C; method C= POC1,; method D= R4R4'NH; method E=(1) NaOH, H, O,(2) H30+; method F= K2C03, RSX, KI, DMF; method G=(1) SOCl,,(2) R'OH; method H=(1) SOCI,,(2) R5R5'NH; method I=(1) CDI,(2) R5R5'NH. bR1= alkyl; R3= H, methyl; R4, R4'= H, alkyl; R5= alkyl, alkenyl, alkynyl, phenyl, benzyl; R5'= H, alkyl, alkenyl, ...