ProteoFind: A script for finding proteins that are suitable for chemical synthesis

Akira Shigenaga, Naoto Naruse, Akira Otaka

Index: 10.1016/j.tet.2018.03.030

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Abstract

ProteoFind is a computational script for finding proteins that are suitable for fragment ligation-based chemical synthesis. This paper describes the development and case studies of ProteoFind, which searches protein lists obtained from the UniProt website. Its application to visualize areas covered by several one-pot three-fragment ligation methods is also discussed. The results demonstrate that ProteoFind not only saves time when searching for synthetic target proteins, but also proposes many candidate proteins from among which biomedically interesting proteins could be found. It also enables clarification of the features of ligation methods by comparing the areas to which each ligation reaction is accessible.