Tetrahedron 2018-03-10

Rhodium-catalyzed reactions of 3-diazoindolin-2-imines with enamines and their extensions towards 5H-pyrazino[2,3-b]indoles

Guorong Sheng, Shicong Ma, Songlin Bai, Jing Qian, Kai Huang, Bo Lang, Ping Lu, Yanguang Wang

Index: 10.1016/j.tet.2018.03.021

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Abstract

The rhodium-catalyzed reactions of 3-diazoindolin-2-imines with β-enamino esters furnished 2,3-diaminoindoles in excellent yields with wide functional group tolerance. The synthesized 2,3-diaminoindoles could be converted into 5H-pyrazino [2,3-b]indoles via a sequential dehydrogenation/6π-ERC/aromatization process.

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