Tetrahedron 2018-03-07

Facile synthesis of perfluoroalkylated fluorenes via a one-pot two-step three-component process

Zhenhua Sun, Qi Huang, Jing Han, Weimin He, Jie Chen, Yuchen Xu, Hongmei Deng, Min Shao, Hui Zhang, Weiguo Cao

Index: 10.1016/j.tet.2018.03.012

Full Text: HTML

Abstract

The efficient synthesis of perfluoroalkyl-substituted fluorenes directly from indenones, malononitrile and methyl perfluoroalk-2-ynoates via a one-pot two-step three-component cascade process is reported. Up to 12 examples of indenones with various substituents were converted into their corresponding functionalized fluorene derivatives in good to excellent yields.

Latest Articles:

Synthesis of chiral α-amino anilides via a DMEDA-promoted selective C─N coupling reaction of aryl halides and α-aminoamides

2018-04-11

[10.1016/j.tet.2018.03.003]

A site isolation-enabled organocatalytic approach to enantiopure γ-amino alcohol drugs

2018-04-11

[10.1016/j.tet.2018.04.022]

Chemoselectivity in the Kosugi-Migita-Stille coupling of bromophenyl triflates and bromo-nitrophenyl triflates with (ethenyl)tributyltin

2018-04-10

[10.1016/j.tet.2018.02.051]

Process design methodology for organometallic chemistry in continuous flow systems

2018-04-07

[10.1016/j.tet.2018.04.020]

Substrate engineering: Effects of different N-protecting groups in the CAL-B-catalysed asymmetric O-acylation of 1-hydroxymethyl-tetrahydro-β-carbolines

2018-04-07

[10.1016/j.tet.2018.04.012]

More Articles...