Tetrahedron 2018-03-07

Isa‒NHC‒catalyzed intermolecular stetter reaction of aromatic aldehydes with maleimides: An efficient access to 3‒aroylsuccinimides

Milind M. Ahire, Santosh B. Mhaske

Index: 10.1016/j.tet.2018.03.009

Full Text: HTML

Abstract

An intermolecular Stetter reaction of aromatic aldehydes with maleimides has been developed using thiazolylidene salt derived Isa‒NHC as an efficient organocatalyst. The synthesized Stetter products “3‒aroylsuccinimides” are important building blocks for the synthesis of natural products and bioactive compounds. The reaction conditions are mild, and various substituents on aromatic aldehyde and maleimide nitrogen were tolerated.

Latest Articles:

Synthesis of chiral α-amino anilides via a DMEDA-promoted selective C─N coupling reaction of aryl halides and α-aminoamides

2018-04-11

[10.1016/j.tet.2018.03.003]

A site isolation-enabled organocatalytic approach to enantiopure γ-amino alcohol drugs

2018-04-11

[10.1016/j.tet.2018.04.022]

Chemoselectivity in the Kosugi-Migita-Stille coupling of bromophenyl triflates and bromo-nitrophenyl triflates with (ethenyl)tributyltin

2018-04-10

[10.1016/j.tet.2018.02.051]

Process design methodology for organometallic chemistry in continuous flow systems

2018-04-07

[10.1016/j.tet.2018.04.020]

Substrate engineering: Effects of different N-protecting groups in the CAL-B-catalysed asymmetric O-acylation of 1-hydroxymethyl-tetrahydro-β-carbolines

2018-04-07

[10.1016/j.tet.2018.04.012]

More Articles...