European Journal of Organic Chemistry 2018-02-22

POCl3‐Promoted Trifluoromethylthiolation‐based Vicinal Bifunctionalization of Indoles with CF3SO2Na

Jin-Tao Liu; Dong-Wei Sun; Xu Jiang; Min Jiang; Yun Lin

Index: 10.1002/ejoc.201800249

Full Text: HTML

Abstract

An efficient trifluoromethylthiolation‐based vicinal bifunctionalization of indoles with sodium trifluoromethanesulfinate in the presence of phosphorus oxychloride were achieved to introduce a chlorine atom into the 2‐position under transition‐metal‐free and mild conditions. The protocol could also extend to other sodium perfluoroalkanesulfinates or phosphorus oxybromide.

Latest Articles:

Development of Photoactivatable Nitroxyl (HNO) Donors Incorporating the (3‐Hydroxy‐2‐naphthalenyl)methyl Phototrigger

2018-04-15

[10.1002/ejoc.201800092]

Catalytic C‐Alkylation of Pyrroles with Primary Alcohols: Hans Fischer's Alkali and a New Method with Iridium P,N,P‐Pincer Complexes

2018-03-30

[10.1002/ejoc.201800146]

Fluorine‐Containing Functionalized Cyclopentene Scaffolds Through Ring Contraction and Deoxofluorination of Various Substituted Cyclohexenes

2018-03-30

[10.1002/ejoc.201800057]

Verdazyl Radical Building Blocks: Synthesis, Structure, and Sonogashira Cross‐Coupling Reactions

2018-03-30

[10.1002/ejoc.201701783]

Iron‐Catalyzed Sulfur‐Promoted Decyanative Redox Condensation of o‐Nitrophenols and Arylacetonitriles: An Unprecedented Route to 2‐Arylbenzoxazoles

2018-03-30

[10.1002/ejoc.201701607]

More Articles...