Amnesia-reversal activity of a series of N-[(disubstituted-amino) alkyl]-2-oxo-1-pyrrolidineacetamides, including pramiracetam

…, YJ L'Italien, L Zweisler, PH Poschel…

Index: Butler; Nordin; L'Italien; Zweisler; Poschel; Marriott Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 684 - 691

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Citation Number: 36

Abstract

A series of N-[(dialkylamino) alkyl]-2-oxo-l-pyrrolidineacetamides was synthesized. The title compounds reversed electroconvulsive shock (ECS) induced amnesia in mice when administered subsequent to the ECS treatment and were inactive in a general observational test for central nervous system (CNS) activity. Active compounds exhibited an inverted U- shaped dose-response curve. Among the compounds with the broadest dose-response ...