Palladium-catalyzed carbonyl insertion route to pyrido [2-1-b] quinazoline derivatives
…, DL Coffen, BH Schaer, J Lind
Index: Tilley, Jefferson W.; Coffen, David L.; Schaer, Beatrice H.; Lind, Joan Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2469 - 2474
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Citation Number: 32
Abstract
A synthesis of 8-substituted pyrido [2, 1-b] quinazoline derivatives is described involving as the key step the palladium-catalyzed carbonyl insertion reaction of 5-substituted 2-(2- bromoanilino) pyridines. This methodology provides a new and flexible route to the ppido [2, 1-b] quinazoline and related ring systems.
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[Tilley, Jefferson W.; Levitan, Paul; Lind, Joan; Welton, Ann F.; Crowley, Herman J.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 185 - 193]
[Tilley, Jefferson W.; Levitan, Paul; Lind, Joan; Welton, Ann F.; Crowley, Herman J.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 185 - 193]