Synthesis of a benzolactone collection using click chemistry

J Ritschel, F Sasse, ME Maier

Index: Ritschel, Jan; Sasse, Florenz; Maier, Martin E. European Journal of Organic Chemistry, 2007 , # 1 p. 78 - 87

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Citation Number: 18

Abstract

Abstract A collection of benzotriazoles consisting of seven compounds was prepared from the propynyl-substituted benzolactone 1 and various azides using click chemistry. The lactone 1 was obtained through a short route by direct esterification of the allylbenzoic acid 9 with the alkynol 7 giving the benzoate 2. The homopropargyl alcohol 7 in turn was obtained by opening the epoxide 6 with triisopropylsilyl acetylide. Ring-closing metathesis of the ...