Organometallics

Synthesis of 1-amino-2-phenylethane-1-boronic acid derivatives

DS Matteson, KM Sadhu

Index: Matteson, Donald S.; Sadhu, Kizhakethil Mathew Organometallics, 1984 , vol. 3, p. 614 - 618

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Citation Number: 91

Abstract

Results The successful synthetic route is based on Majumdar's observation of the stability of (dialky1amino) methaneboronic esters5 and his efficient new synthesis of a-chloro boronic ester^,^ as well as his observation of SN2 displacement on an a-chloro boronic ester by a highly hindered dialkylamide.'O Thus, ethylene glycol benzylboronate (la) with (dich10romethyl) lithium~ yielded ethylene glycol 1-chloro-2-phenylethane-1-boronate ( ...