Studies on anti-inflammatory agents. VI. Synthesis and pharmacological properties of 2, 3-diarylthiophenes.
…, K Nakamura, T OGiNo, N KoNisHi, T TOJO…
Index: Tsuji, Kiyoshi; Nakamura, Katsuya; Ogino, Takashi; Konishi, Nobukiyo; Tojo, Takashi; Ochi, Takehiro; Seki, Nobuo; Matsuo, Masaaki Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 279 - 286
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Citation Number: 40
Abstract
A series of novel 5-substituted-2, 3-diarylthiophenes has been synthesized and found to be active in the rat adjuvant arthritis (AA) model and/or in the yeast-induced hyperalgesia (Randall-Selitto) assay. Among the compounds synthesized herein, 2-(4-fluorophenyl)-3-[4- (methylsulfonyl) phenyl]-5-(trifluoromethyl) thiophene (6a) exhibited the most potent activities on AA, collagen-induced arthritis (CIA) and the delayed-type hypersensitivity ...
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