Design, synthesis, and evaluation of anti-inflammatory and ulcerogenicity of novel pyridazinone derivatives

…, NA Khalil, EM Ahmed, A Esmat, AM Al-Abd

Index: Abouzid; Khalil; Ahmed; Esmat; Al-Abd Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3581 - 3590

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Citation Number: 9

Abstract

Abstract A series of pyridazinone-containing compounds were designed and synthesized as congeners for diclofenac, the most potent and widely used NSAID. The target compounds were evaluated for their anti-inflammatory activity on rat paw edema inflammation model against diclofenac as a reference compound. Seven of the tested compounds demonstrated more than 50% inhibition of carrageenan-induced rat paw edema at a dose 10 mg/kg. The ...