Synthesis and Biological Evaluation of New Multifunctional Oxazolone Scaffolds Incorporating Phenyl Benzoate Moiety

Ebrahim Abdel‐Galil; Evelin B. Moawad; Ahmed El‐Mekabaty; Gehad E. Said

Index: 10.1002/jhet.3139

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Abstract

Oxazolone derivative 3a was utilized as a versatile precursor for the construction of new heterocyclic scaffolds containing imidazole, oxazine, triazine, and triazole rings (compounds 20, 21, 23, and 24, respectively). Furthermore, 4‐aminohippuric acid (2b) was used in the synthesis of various new oxazolone derivatives (13–19) by utilizing of its amino group in several transformations followed by heterocyclization of these compounds with aldehyde 1 via classical Erlenmeyer condensation method to give the targeted oxazolones. On evaluation of these compounds as antioxidant and antibacterial agents, compounds 20 and 24 exhibited a good antioxidant activity, while compounds 20, 23, and 24 exhibited a good antibacterial activity against Escherichia coli and Staphylococcus aureus.