Journal of medicinal chemistry

Quantitative structure-activity relationships of 6-anilinouracils as inhibitors of Bacillus subtilis DNA polymerase III

GE Wright, JJ Gambino

Index: Wright, George E.; Gambino, Joseph J. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 181 - 185

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Citation Number: 46

Abstract

Quantitative structure-activity relationships (QSAR) of a series of 6-anilinouracil derivatives were developed for their inhibitory activity against the wild-type DNA polymerase I11 (pol 111) and a mutant enzyme, pol III/azp-12, derived from Bacillus subtilis. Interaction between inhibitors and both enzymes appears to result solely from hydrophobic binding. Comparison of the substituent contributions indicates increased hydrophobic character and a minor ...